COVID-19 Convalescent Plasma Program

A world-renowned leader in infectious disease and transfusion medicine research, Vitalant Research Institute (VRI)—a division of Vitalant—is helping direct collection of blood plasma donations from recovered COVID-19 patients and developing technologies to detect and quantify virus-fighting antibodies. Recovered COVID-19 patients may have immune-boosting antibodies in their plasma; that plasma—called “convalescent plasma”—could be used to treat critically ill COVID-19 patients.

On Sunday, August 23, 2020, the U.S. Food and Drug Administration (FDA) issues an Emergency Use Authorization (EUA) for COVID-19 Convalescent Plasma (CCP) for the treatment of COVID-19 in hospitalized patients. Vitalant sent a communication to hospital partners on August 28, 2020 outlining what we know now about EUA impacts. View that communication here.

We also shared information during a webinar on September 2, 2020. You can access a recording of this webinar here, a copy of the PowerPoint shared during the webinar (current as of September 9, 2020) here and a Q&A resource (current as of September 9, 2020) here.

 
Frequently Asked Questions about Vitalant's Convalescent Plasma Program
The following information is not applicable to some Vitalant locations, notably in the Northeast. If the process described below is unfamiliar to you, please reach out to your account representative.

How does a current, contracted hospital customer obtain convalescent plasma from Vitalant?
Once a contracted customer has worked with their local contact(s) and taken the necessary steps to be part of Vitalant’s convalescent plasma program, they can take the following steps to order CCP. If you are unsure if your facility is a part of the program, please contact your account representative for guidance.

Request all convalescent products through the online ordering portal, following these steps (screen shots below for visual):
  • Select the type of order priority needed
  • Under the Family tab, choose Plasmas
  • Enter the number of products needed for ABO Type
    • Up to two convalescent products can be ordered for a patient
  • Select the Modifiers tab, pick Convalescent Plasma
  • Select Add product
  • Click Proceed for products to be requested
  • Enter comments to communicate special needs, examples include:
    • ABO incompatible accepted
    • Type compatible preferred
    • Immediate patient need


A Vitalant medical doctor is available for consultation regarding transfusing incompatible plasma. Please contact your Hospital Services Department for more information.

How does a non-contracted hospital obtain convalescent plasma from Vitalant?
Non-contracted customers can reach out to Vitalant’s Inventory Management team at ProductManagement@vitalant.org or to discuss potential convalescent plasma ordering.

Where can your organization get the most up-to-date information about convalescent plasma?
This website is where we will maintain up-to-date information about the convalescent plasma program. We will continue to send email communications with major updates and required actions but please use this webpage as a frequently-checked resource at your organization.

If your organization is interested in the emergency use of investigational COVID-19 convalescent plasma, we strongly recommend you visit the FDA’s webpage regarding “Recommendations for Investigational COVID-19 Convalescent Plasma” for more information about how your facility should work directly with the FDA to prepare.

Who should I contact at Vitalant about its convalescent plasma program?
If you represent a facility that has interest/need to transfuse active COVID-19 patients please reach out to your area’s Regional Account Manager and Medical Director with questions/inquiries.
 
For questions regarding reimbursement for CCP products under various INDs/programs, please reach out to your Vitalant contact.

ISBT Codes and Labels for customers who receive CCP units from Vitalant:


The following codes are the original codes provided when CCP became available. It is high priority to verify these are entered in your system and this should be confirmation only.

Special testing codes, or modifiers, to differentiate low titer/high titer CCP products for the following codes:
  • N0137: High titer for SARS-CoV-2 antibody
  • N0138: Low titer for SARS-CoV-2 antibody
Apheresis CCP
Description ISBT 128 Code Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|COVID-19 E9747V00*
Previously Provided
Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<= -18C|Irradiated|COVID-19 E9753V00*
Previously Provided
 
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|COVID-19 E9752V00*
Previously Provided
Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|1st container|COVID-19   E9754V00*
Previously Provided
Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|2nd container|COVID-19  E9755V00*
Previously Provided
Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|3rd container|COVID-19   E9756V00*
Previously Provided
Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|4th container|COVID-19    E9757V00*
Previously Provided
Label Example
 *Divided Code: VA0 - VE0

Whole Blood Derived CCP
Description ISBT 128 Code Label Example
CONVALESCENT PLASMA|CP2D/XX/<=-18C|COVID-19 E9802V00
Previously Provided
Label Example
CONVALESCENT PLASMA|CPD/XX/<=-18C|COVID-19 E9735V00
Previously Provided
Label Example
CONVALESCENT PLASMA|CPDA-1/XX/<=-18C|COVID-19 E9804V00
Previously Provided
Label Example
 
Psoralen Treated CCP
Description ISBT 128 Code Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|Psoralen-treated|COVID-19 E9771V00*
Previously Provided
 
*Divided Code: VA0 - VE0

The following codes were released by ICCBBA on November 6, 2020 to meet FDA EUA requirements for designating low and high titer CCP products.

Apheresis CCP (High Titer = HIGH priority to enter; Low Titer = LOW priority to enter)
Description ISBT 128 Code Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|COVID-19 high titer EA160V00* Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|COVID-19 low titer EA161V00*  
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|1st container|COVID-19 high titer EA166V00* Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|1st container|COVID-19 low titer EA167V00*  
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|2nd container|COVID-19 high titer EA168V00* Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|2nd container|COVID-19 low titer EA169V00*  
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|3rd container|COVID-19 high titer EA170V00* Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|3rd container|COVID-19 low titer EA171V00*  
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|4th container|COVID-19 high titer EA172V00* Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|4th container|COVID-19 low titer EA173V00*  
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|5th container|COVID-19 high titer EA296V00*  
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|5th container|COVID-19 low titer EA297V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|COVID-19 high titer EA162V00* Label Example
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|COVID-19 low titer EA163V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|1st container|COVID-19 high titer EA182V00* Label Example
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|1st container|COVID-19 low titer EA183V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|2nd container|COVID-19 high titer EA184V00* Label Example
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|2nd container|COVID-19 low titer EA185V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|3rd container|COVID-19 high titer EA186V00* Label Example
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|3rd container|COVID-19 low titer EA187V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|4th container|COVID-19 high titer EA188V00* Label Example
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|4th container|COVID-19 low titer EA189V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|5th container|COVID-19 high titer EA298V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|5th container|COVID-19 low titer EA299V00*  
*Divided Code: VA0 - VE0

Whole Blood Derived CCP (High Titer = HIGH priority to enter; Low Titer = LOW priority to enter)
Description ISBT 128 Code Label Example
CONVALESCENT PLASMA|CP2D/XX/<=-18C|COVID-19 high titer EA258V00 Label Example
CONVALESCENT PLASMA|CP2D/XX/<=-18C|COVID-19 low titer EA259V00  
CONVALESCENT PLASMA|CPDA-1/XX/<=-18C|COVID-19 high titer EA262V00 Label Example
CONVALESCENT PLASMA|CPDA-1/XX/<=-18C|COVID-19 low titer EA263V00  
CONVALESCENT PLASMA|CPD/XX/<=-18C|COVID-19 high titer EA393V00
(added 1-25-21)
Label Example
CONVALESCENT PLASMA|CPD/XX/<=-18C|COVID-19 low titer EA394V00
(added 1-25-21)
 
Thawed CONVALESCENT PLASMA|CPD/XX/refg|COVID-19 high titer EA218V00 Label Example
Thawed CONVALESCENT PLASMA|CPD/XX/refg|COVID-19 low titer EA219V00  
Thawed CONVALESCENT PLASMA|CP2D/XX/refg|COVID-19 high titer EA260V00 Label Example
Thawed CONVALESCENT PLASMA|CP2D/XX/refg|COVID-19 low titer EA261V00  
Thawed CONVALESCENT PLASMA|CPDA-1/XX/refg|COVID-19 high titer EA276V00 Label Example
Thawed CONVALESCENT PLASMA|CPDA-1/XX/refg|COVID-19 low titer EA277V00  

  Psoralen Treated CCP (LOW priority to enter)
Description ISBT 128 Code Label Example
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|Psoralen-treated|COVID-19 high titer EA200V00*  
Apheresis CONVALESCENT PLASMA|ACD-A/XX/<=-18C|Psoralen-treated|COVID-19 low titer EA201V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|Psoralen-treated|COVID-19 high titer EA234V00*  
Thawed Apheresis CONVALESCENT PLASMA|ACD-A/XX/refg|Psoralen-treated|COVID-19 low titer EA235V00*  
*Divided Code: VA0 - VE0